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What is Merional?

Merional is a mixture of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Merional helps the following the condition:

  • For causing ovulation in women to help them become pregnant
  • For producing sperm in men

Merional Injection contains Human Menopausal Gonadotropin as an active ingredient. Merional works by possessing the controlled ovarian stimulation activity. Merional contains natural hormones used to stimulate the ovaries in the expectation of promoting the growth of several egg cells in the period of 8 or more days.

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What is Merional Used For?

Merional is used for female and male infertility. Merional contains FSH which is essential for the Growth of Ovarian Follicles. Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) Stimulate Healthy Ovaries to make eggs. Merional is given by injection. Use Merional if your healthcare provider has instructed you.

How To Use Merional?

Merional is administered under the skin. The recommended initial Dose of Merional for patients who have received a GnRH agonist for pituitary suppression is 225 IU. The maximum daily dose should not exceed 450 IU and a dose beyond 20 days is not recommended. Do not take Merional without the instructions of the doctor.

Why Merional is Prescribed?

Merional injection is an equal mixture of the naturally occurring Follicle-Stimulating Hormone (FSH) and luteinizing hormone (LH) used to stimulate ovulation when a woman's ovaries can produce a follicle but hormonal stimulation is deficient. Merional is also used to stimulate the development of multiple eggs for in Vitro Fertilization and is likewise used to stimulate the production of sperm in men who have functioning testes but in whom hormonal stimulation is deficient.

What Conditions Does Merional Treat?

Merional, in conjunction with hCG, is indicated for Multiple Follicular Developments (controlled ovarian stimulation) and ovulation induction in patients who have previously received pituitary suppression. Treatment With Merional should be initiated under the supervision of a physician experienced in the treatment of fertility issues. 

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Merional Dosage

  • Initial Merional dose of the first cycle - 225 International Units per day,
  • Dosage adjustments after 5 days and by no more than 150 International Units 
  • Do not administer Merional doses greater than 450 International Units per day (2.2)
  • If your doctor has recommended you a different dose, you should follow that. 

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Side Effects of Merional:

Common side effects include but are not limited to:

  • Pulmonary and vascular complications
  • Ovarian Hyperstimulation Syndrome
  • Hemoperitoneum
  • Adnexal torsion
  • Mild to moderate ovarian enlargement
  • Ovarian cysts
  • Abdominal pain
  • Sensitivity to Merional
  • Gastrointestinal symptoms
  • Pain, rash, swelling, and/or irritation at the site of injection
  • Body rashes
  • Dizziness, tachycardia, dyspnea, tachypnea
  • Ectopic pregnancy
  • Congenital abnormalities

Cautions To Take Merional:

Do not use Merional if you:

  • Have failed ovaries
  • Are pregnant 
  • Have uncontrolled thyroid gland disorder
  • Have cancer of ovaries, breasts, or uterus.
  • Have a tumour of the pituitary gland or in the brain.
  • Have heavy or irregular vaginal bleeding 
  • Have ovarian cysts or enlarged ovaries

Frequently Asked Questions

1. Who should not use Merional?

Merional should not be administered to children or to patients who have:

  • Hypersensitivity to the active substance menotropins or to any of the excipients
  • Tumours of the hypothalamus or pituitary gland and to females who have
  • Ovarian enlargement or a cyst not due to polycystic ovarian disease
  • Gynaecological haemorrhages of unknown cause
  • Ovarian, uterine or mammary carcinoma

Merional should not be used when an effective response cannot be achieved, such as:

In females:

  • Primary ovarian failure
  • Malformation of sexual organs incompatible with pregnancy
  • Fibroid tumours of the uterus incompatible with pregnancy

In males:

  • Primary testicular insufficiency
2. What should I do if I miss a dose?

You should take the missed dose as soon as you remember. However, if it is time for the next scheduled dose, skip the missed one and take your next dose. Do not take a double dose to make up the missed one.

3. Is it safe to drive or operate heavy machinery while using Merional

If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Merional Injection medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively.

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